Preheat oven to 375 degrees.

Add cranberries, sugar, water and about half of the orange zest to a medium saucepan, and stir to combine. Bring to a boil over high heat, then reduce heat to medium-low and simmer for 10 minutes. Meanwhile, line a baking sheet with parchment paper or aluminum foil, and place the brie in the center of the sheet. Bake for 10 minutes, or until the cheese is melted and just begins to ooze out the side. Transfer baked brie to a serving tray. Then top with the cranberry sauce, and sprinkle with pistachios and remaining orange zest.

Serve immediately with crackers.